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These results show that HNE protects macrophages from LPS/nigericin-mediated pyroptosis

It is becoming clear that aspartate is a significant metabolic hub, and a major product of the oxidative glutaminolysis pathway

When ARA-290 binds to the IRR, it does two critical things: It shuts down inflammation: It tells the immune system to stop attacking the damaged area, switching the focus from "defense" to "reconstruction." It stimulates regeneration: It promotes the sprouting of small nerve fibers, which are often the first to die in conditions like Small Fiber Neuropathy (SFN)

ICP22-mediated inhibition of apoptosis likely involves p53, a cellular transcription factor that controls apoptosis by activating Bax or inhibiting Bcl-2, and that has been shown to be antagonized by ICP22 which promotes cell survival (Figure 2A